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This is why oral administration is most defensible for GI-specific indications

For example, we know that the uptake of apoptotic bodies can lead to immunosuppression (84)

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An important systemic consequence of AKI is its effects on energy metabolism and redox balance

Large amounts of iron are found in the basal ganglia, substantia nigra, and cerebellum, likely reflecting the high metabolic demand and active neurotransmitter synthesis in these regions (Ghaderi et al